Related Experiment Video

Updated: Jun 10, 2026

Defining Hsp33's Redox-regulated Chaperone Activity and Mapping Conformational Changes on Hsp33 Using Hydrogen-deuterium Exchange Mass Spectrometry
10:24

Defining Hsp33's Redox-regulated Chaperone Activity and Mapping Conformational Changes on Hsp33 Using Hydrogen-deuterium Exchange Mass Spectrometry

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mRNA 3' UTRs chaperone intrinsically disordered regions to control protein activity

Yang Luo1, Yaofeng Zhong2, Sudipto Basu1

  • 1Cancer Biology and Genetics Program, Sloan Kettering Institute, New York, NY 10065, USA.

Cell
|June 8, 2026
PubMed
Abstract

Keywords:
3′ UTRRNA multivalencyRNA-based chaperone activityRNA–IDR interactionchromatin regulatorco-translationalcrosslinking mass spectrometryhydrophobic clustersintrinsically disordered regionsmesh-like condensatesprotein foldingtranscription factor

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