Related Experiment Video
Updated: Jun 10, 2026

Augmenting Large Language Models via Vector Embeddings to Improve Domain-Specific Responsiveness
Published on: December 6, 2024
The Role of Large Language Models in Scientific Research
Tobias Lindner1,2, Marc-André Weber1,2, Mathias Manzke2
1Rostock University Medical Center, Core Facility Multimodal Small Animal Imaging, Germany, Rostock.
Background:
Large language models (LLMs) are increasingly being incorporated in scientific research, transforming the landscape across disciplines. Their potential spans various stages of the research process - from automating literature reviews and generating research questions to analyzing complex data sets and synthesizing or evaluating manuscripts. However, their implementation presents challenges, especially for researchers with limited experience using AI.
Materials And Methods:
This review describes the potential of LLMs to support and enhance systematic literature searches in scientific research. It analyzes their capabilities and addresses practical and ethical challenges, particularly those concerning scientific integrity, transparency, and reproducibility.
Conclusion:
Combining LLMs with human expertise offers a promising avenue to accelerate innovation, drive scientific discovery, and ultimately improve healthcare outcomes. Nevertheless, responsible and informed use is essential to maintain rigorous, ethical, and trustworthy scientific practices.
Key Points:
· LLMs can accelerate systematic literature searches through automation. · Self-hosted models offer better control, data protection, and domain-specific customization options. · Ethical challenges require transparency, quality assurance, and responsible use of AI.
Citation Format:
· Lindner T, Weber MA, Manzke M. The Role of Large Language Models in Scientific Research. Rofo 2026; DOI 10.1055/a-2868-7797.
Related Concept Videos
Language and Cognition
Language Development
The critical period for language acquisition suggests that the ability to acquire language is at its peak early in life. As people age, this proficiency decreases. Language development begins very...
Improving Translational Accuracy
Improving Translational Accuracy
Language
Corballis and Suddendorf (2007) and Tomasello and Rakoczy (2003) highlight the role of language in...
Higher Mental Functions of the Brain: Language
Language formation and comprehension take place in the dominant hemisphere. The dominant hemisphere is responsible for understanding the meaning of spoken, written, or sign language, as well as the ability to communicate. For most people, the left hemisphere is the dominant one. The right hemisphere, then, gives tone and emotional context to the...