Related Experiment Video
Updated: Jun 10, 2026
06:47
A Murine Model of Vertical Sleeve Gastrectomy
Published on: December 18, 2017
Glycemic Normalization Immediately Following Vertical Sleeve Gastrectomy in Adolescents With Type 2 Diabetes From the
Natalie Segev1,2, Kristen J Nadeau3, Megan Kelsey3
1Division of Diabetes and Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Diabetes, Obesity & Metabolism
|June 8, 2026
Summary
Vertical sleeve gastrectomy (VSG) rapidly normalizes blood glucose in adolescents with type 2 diabetes. This surgical intervention shows significant glycemic improvements shortly after the procedure, even before substantial weight loss occurs.
Area of Science:
- Endocrinology
- Metabolic Disorders
- Pediatric Surgery
Background:
- Youth-onset type 2 diabetes and obesity present significant public health challenges.
- While medications offer some glycemic control, their impact on pediatric weight loss is inconsistent.
- Bariatric surgery, particularly vertical sleeve gastrectomy (VSG), shows promise for improving weight and glycemia in adolescents.
Purpose of the Study:
- To evaluate the immediate glycemic effects of VSG in adolescents with type 2 diabetes.
- To compare glycemic patterns post-VSG with advanced medical therapy (AMT) using continuous glucose monitoring (CGM).
Main Methods:
- The ST2OMP study enrolled 73 adolescents with type 2 diabetes for 14-day CGM monitoring.
- 33 participants were monitored 1-2 days post-VSG; 40 received AMT.
- CGM data analyzed included glucose management indicator (GMI), time in range, and glycemic variability metrics.
Main Results:
- Mean glucose levels were significantly lower in the post-VSG group (84.3 mg/dL) compared to the AMT group (149.8 mg/dL).
- Mean CGM GMI indicated normal glucose control post-VSG (5.3%) versus the diabetes range with AMT (6.9%).
- Post-VSG participants experienced more time below target glucose levels (<70 mg/dL).
Conclusions:
- Adolescents with type 2 diabetes achieve early glycemic normalization following VSG.
- These glycemic improvements occur rapidly after surgery, preceding significant weight reduction.
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