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Related Concept Videos

Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
Model Approaches for Pharmacokinetic Data: Physiological Models01:15

Model Approaches for Pharmacokinetic Data: Physiological Models

Physiological models in pharmacokinetics are instrumental in understanding the distribution and elimination of drugs within the body. These models describe the drug concentration within target organs, influenced by factors such as drug uptake, tissue volume, and blood flow. Drug uptake is governed by the partition coefficient, which signifies the drug concentration ratio in tissue to that in the blood. The blood flow rate to a specific tissue is expressed as Qt, and the rate of change in tissue...
Pharmacokinetic Models: Overview01:20

Pharmacokinetic Models: Overview

Pharmacokinetic models utilize mathematical analysis to achieve a detailed quantitative understanding of a drug's life cycle within the body. They are instrumental in simulating a drug's pharmacokinetic parameters, predicting drug concentrations over time, optimizing dosage regimens, linking concentrations with pharmacologic activity, and estimating potential toxicity.
There are three primary types of models: empirical, compartment, and physiological. Empirical models, with minimal assumptions,...
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of fluid...
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
Pharmacokinetic Models: Comparison and Selection Criterion01:26

Pharmacokinetic Models: Comparison and Selection Criterion

Physiological and compartmental models are valuable tools used in studying biological systems. These models rely on differential equations to maintain mass balance within the system, ensuring an accurate representation of the dynamic processes at play.
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.

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Related Experiment Video

Updated: Jun 10, 2026

An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit: Methodological Considerations, Development, and Assessment
10:31

An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit: Methodological Considerations, Development, and Assessment

Published on: April 20, 2018

Cardiovascular-Kidney-Metabolic Syndrome: Conceptualising an Approach to Health Economic Modelling.

Volker Foos1, Jieling Chen2, Phil McEwan1

  • 1Health Economics and Outcomes Research Ltd, Cardiff, UK.

Diabetes, Obesity & Metabolism
|June 8, 2026
PubMed
Summary

A new conceptual framework and influence diagram were developed to holistically model the Cardiovascular-Kidney-Metabolic (CKM) syndrome. This approach aims to improve health economic evaluations for this global public health crisis.

Keywords:
cardiorenalcardiovascularhealth economic modelmetabolic syndromeobesity

Related Experiment Videos

Last Updated: Jun 10, 2026

An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit: Methodological Considerations, Development, and Assessment
10:31

An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit: Methodological Considerations, Development, and Assessment

Published on: April 20, 2018

Area of Science:

  • Integrative biology and health economics.
  • Multidisciplinary research involving clinical and economic perspectives.

Background:

  • Cardiovascular-Kidney-Metabolic (CKM) syndrome is a significant global health issue.
  • Current health economic models do not fully capture the value of integrated CKM care.
  • There is a need for holistic approaches to CKM syndrome management.

Purpose of the Study:

  • To present a conceptual framework for developing a new health economic model for CKM syndrome.
  • To guide the creation of a model that captures value across interconnected CKM domains.
  • To address the limitations of existing models in representing the complexity of CKM syndrome.

Main Methods:

  • Literature review to identify key biological drivers of CKM syndrome.
  • Development of a biological framework and influence diagram.
  • Iterative refinement of the framework and diagram with expert feedback.

Main Results:

  • A biological framework and influence diagram illustrating CKM syndrome drivers and outcomes were created.
  • The developed diagrams provide a basis for future health economic evaluation models.
  • The rationale behind the connections within the diagrams is detailed.

Conclusions:

  • A significant unmet need exists for comprehensive CKM syndrome modeling.
  • The proposed framework supports evidence-based decision-making for CKM management.
  • Development of a holistic health economic model for CKM syndrome is becoming feasible.