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Updated: Jun 10, 2026

Homogeneous Time-resolved Förster Resonance Energy Transfer-based Assay for Detection of Insulin Secretion
Published on: May 10, 2018
PROTAC-Mediated DPP-4 Degradation: A New Solution for Type 2 Diabetes
1Institute of Functional Nano & Soft Materials (FUNSOM), Biomedical Basic Research Center (BBRC) of Jiangsu Province, Engineering Research Center of RNA Medicine and Cell Therapy Technology, Ministry of Education, Soochow University, 199 Ren'ai Road, Suzhou, 215123 Jiangsu, PR China.
Abstract:
Dipeptidyl peptidase-4 (DPP-4) is an important aggravating factor in the progression and exacerbation of type 2 diabetes mellitus (T2DM), a condition characterized by diminished insulin responsiveness because it rapidly degrades glucagon-like peptide-1 (GLP-1) and other peptide with similar physiological function. Although several small-molecule DPP-4 inhibitors have been developed for the clinical management of T2DM, their therapeutic benefits are only moderate, as the fail to achieve for sustained inhibition of DPP-4. Hence, targeted degradation of DPP-4 using proteolysis-targeting chimera (PROTAC) technology offers an alternative strategy for sustained glycemic control in T2DM.
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