Validity and Responsiveness of Chronic Rhinosinusitis Control Test Subdomains.

Area of Science:

• Otolaryngology
• Clinical Outcomes Research
• Psychometrics

Background:

• Chronic rhinosinusitis (CRS) control is assessed using patient-reported outcomes.
• The Chronic Rhinosinusitis Control Test (CRCT) includes sinonasal and impairment subdomains.
• Psychometric validation of these CRCT subdomains is essential for reliable assessment.

Purpose of the Study:

• To psychometrically validate the sinonasal and impairment subdomains of the CRCT.
• To establish criterion validity and responsiveness of the CRCT subdomain scores.
• To determine Minimal Clinically Important Difference (MCID) values for the CRCT subdomains.

Main Methods:

• A cohort of 701 adult CRS patients completed CRCT, OSS, SNOT-22, and EQ-5D.
• Responsiveness to change was assessed in a subset of 283 patients.
• Validation involved criterion validity, responsiveness, and MCID determination using distribution- and anchor-based methods.

Main Results:

• CRCT subdomain scores significantly correlate with and respond to measures of CRS symptom severity and quality of life.
• The sinonasal subdomain reflects sinonasal symptom burden with an MCID of ≥3 points.
• The impairment subdomain reflects general quality of life with an MCID of ≥1 point.

Conclusions:

• CRCT sinonasal and impairment subdomains are psychometrically validated outcome measures.
• These subdomains provide additional insights into CRS disease state and overall control.
• Established MCID values serve as benchmarks for assessing changes in CRCT subdomain scores.