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Rare ALK-IR (Intergenic Region) Rearrangement in a Patient with Non-Small Cell Lung Cancer: A Case Report

Qingtao Ni1, Chi Pan2, Guangzhi Sun1

  • 1Department of Oncology, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou, 225300, China.

Current Cancer Drug Targets
|June 9, 2026
PubMed
Abstract

Insights

This case study reports the first instance of an anaplastic lymphoma kinase (ALK) intergenic region (IR) rearrangement in non-small cell lung cancer (NSCLC). Crizotinib treatment led to significant remission in this patient.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Non-small cell lung cancer (NSCLC) is the most common type of lung cancer.
  • Anaplastic lymphoma kinase (ALK) rearrangements are key oncogenic drivers in a subset of NSCLC cases.
  • ALK inhibitors have significantly improved outcomes for patients with ALK-positive NSCLC.
Keywords:
ALK-intergenic region rearrangementcase report.crizotinibnon-small cell lung cancerpartial remissiontargeted therapy

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