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Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer

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Spiegelmer Aptamers: Innovative Approach in Breast Cancer.

Yalda Amiri Hezave¹, Rezvan Najafi¹, Razieh Amini¹

¹Research Center for Molecular Medicine, Institute of Cancer, Hamadan University of Medical Sciences, Hamadan, Iran.

Breast Cancer : Basic and Clinical Research

|June 9, 2026

Summary

Spiegelmers, a new class of stable aptamers, show promise for breast cancer diagnosis and therapy. These molecules offer improved stability and targeting for advanced theranostic applications in cancer care.

Keywords:

L-nucleotides SELEX breast cancer spiegelmer aptamers triple-negative breast cancer

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Published on: June 13, 2014

Area of Science:

Biotechnology
Oncology
Molecular Medicine

Background:

Breast cancer necessitates advanced diagnostic and therapeutic solutions due to high mortality rates.
Traditional aptamers face clinical limitations due to instability in biological environments.
Spiegelmers, mirror-image aptamers, offer enhanced stability and nuclease resistance.

Purpose of the Study:

To explore the potential of spiegelmers as a next-generation platform for breast cancer theranostics.
To evaluate spiegelmer applications in molecular imaging, targeted drug delivery, and therapy.
To investigate spiegelmer efficacy against oncogenic microRNAs in aggressive breast cancer subtypes.

Main Methods:

Development and characterization of spiegelmers targeting breast cancer biomarkers.
Conjugation of spiegelmers with imaging agents (MRI, PET) and therapeutic payloads.
Assessment of spiegelmer binding affinity, stability, and in vitro/in vivo anti-cancer activity.
Evaluation of spiegelmer-mediated inhibition of specific microRNAs (e.g., miR-155).

Main Results:

Spiegelmers exhibit high binding specificity and stability in biological systems.
Conjugated spiegelmers show potential for accurate molecular imaging of breast tumors.
Spiegelmers enable targeted drug delivery and therapeutic modalities like photodynamic therapy.
Inhibition of oncogenic miR-155 by spiegelmers demonstrates therapeutic potential for aggressive breast cancer.

Conclusions:

Spiegelmers represent a promising, biostable platform for advanced breast cancer theranostics.
Their versatility supports integrated diagnostic and personalized therapeutic strategies.
Spiegelmers offer a novel approach to managing challenging breast cancer subtypes, including triple-negative breast cancer.