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Updated: Jun 10, 2026
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Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
Published on: July 21, 2018
KRT14 Drives Basal Muscle-Invasive Bladder Cancer Progression and Lung Metastasis by Directly Binding to and
Shirui Huang1,2, Zhihan Zhou1,2, Qipeng Xie2
1Key Laboratory of Medicine, Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Summary
Researchers identified the KRT14-IGF2BP1 signaling axis as a key driver of basal-type muscle-invasive bladder cancer (BMIBC) progression and metastasis. Inhibiting this axis suppressed tumor growth and spread in preclinical models.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Research
Background:
- Basal-type muscle-invasive bladder cancer (BMIBC) presents aggressive metastatic potential and poor prognosis.
- Current therapeutic strategies for BMIBC are limited due to a lack of molecularly defined targets.
Purpose of the Study:
- To identify and characterize novel molecular drivers and therapeutic targets in BMIBC.
- To elucidate the role of the KRT14-IGF2BP1 signaling axis in BMIBC progression and metastasis.
Main Methods:
- Integrative analyses of clinical cohorts and BBN-induced mouse models.
- Investigated the mechanistic interaction between KRT14 and IGF2BP1.
- Assessed the functional impact of disrupting the KRT14-IGF2BP1 axis on tumor progression and metastasis.
Main Results:
- KRT14 was identified as a core oncogenic driver orchestrating the KRT14-IGF2BP1 signaling axis.
- The interaction between KRT14 and IGF2BP1 promotes BMIBC progression and lung metastasis via a positive feedback loop.
- Disruption of the KRT14-IGF2BP1 axis significantly suppressed primary tumor growth and lung metastasis in BMIBC models.
Conclusions:
- The KRT14-IGF2BP1 axis represents a previously unrecognized vulnerability in BMIBC.
- Targeting the KRT14-IGF2BP1 axis holds potential for novel therapeutic strategies to limit aggressive disease progression in BMIBC.
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