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Updated: Jun 10, 2026
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Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
Published on: July 10, 2012
Survival With β-Adrenergic Suppression After Lung Transplantation
Thomas Konecny1,2, Cyrus K Khalily1,2, Alex Nusbickel1,2
1University of Florida, College of Medicine Gainesville FL USA.
Journal of the American Heart Association
|June 9, 2026
Summary
Beta-adrenergic suppression (BAS) after lung transplant (LT) is linked to improved survival. This benefit was observed in patients continuing or starting BAS post-LT, suggesting its potential role in enhancing outcomes.
Area of Science:
- Cardiology
- Pulmonology
- Transplantation Medicine
Background:
- Lung transplant (LT) survival remains a challenge.
- Cardiac arrhythmias are linked to adverse LT outcomes.
- The role of beta-adrenergic suppression (BAS) post-LT is unclear.
Purpose of the Study:
- To investigate the association between beta-adrenergic suppression (BAS) and long-term survival after lung transplant (LT).
- To determine if BAS initiated or continued post-LT impacts patient survival.
Main Methods:
- Retrospective observational study of 299 adult LT recipients (2016-2021).
- Correlated pre- and post-LT antiarrhythmic medication use with long-term survival.
- Adjusted for potential confounders in survival analysis.
Main Results:
- 70% of LT recipients (209/299) were prescribed BAS post-LT.
- BAS prescription correlated with prolonged survival (P=0.008).
- Survival benefit observed for both new BAS initiation and continuation of pre-existing BAS therapy (P=0.03 for both).
Conclusions:
- BAS prescription is associated with prolonged survival after LT.
- This association holds for patients initiating or continuing BAS.
- Further prospective studies are warranted to confirm the beneficial role of BAS post-LT.
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