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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

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Structure-Function Correlation of Virtual Reality and Standard Perimetry With Peripapillary RNFL OCT in Glaucoma

Maral Namdari1, Bryce Baugh1, Bangyan Zhang1

  • 1John A. Moran Eye Center, University of Utah, Salt Lake City, UT, USA.

Translational Vision Science & Technology
|June 9, 2026
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Summary

Virtual reality visual field testing (Radius XR) shows structure-function correlations comparable to standard automated perimetry. This technology supports glaucoma assessment and enhances accessibility for patient care.

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Area of Science:

  • Ophthalmology
  • Medical Technology
  • Glaucoma Research

Background:

  • Standard automated perimetry is crucial for glaucoma diagnosis and monitoring.
  • Assessing the structure-function relationship, particularly with peripapillary retinal nerve fiber layer (pp-RNFL) thickness, is key in glaucoma management.
  • Novel technologies are needed to improve the accessibility and integration of visual field testing.

Purpose of the Study:

  • To compare the structure-function relationship of virtual reality-based visual field testing (Radius XR) with standard automated perimetry (SITA Fast/Faster).
  • To evaluate these relationships based on peripapillary retinal nerve fiber layer (pp-RNFL) thickness measured by spectral-domain optical coherence tomography (SD-OCT).

Main Methods:

  • A cross-sectional study involving 116 eyes from 71 patients with glaucoma or suspected glaucoma.
  • Participants underwent visual field testing with Radius XR and standard automated perimetry (SITA Fast or SITA Faster).
  • Peripapillary RNFL thickness was measured using SD-OCT, and structure-function relationships were analyzed using linear mixed-effects models.

Main Results:

  • Structure-function associations were observed across all testing modalities, with R² values of 0.36 for Radius XR, 0.43 for SITA Fast, and 0.29 for SITA Faster.
  • The strongest associations between global pp-RNFL thickness and mean deviation were found in the supratemporal and inferotemporal sectors.
  • Radius XR demonstrated structure-function correlations comparable to standard perimetry, especially in clinically relevant RNFL sectors.

Conclusions:

  • Radius XR offers a structure-function relationship consistent with standard automated perimetry.
  • The findings support the use of Radius XR as a viable tool for glaucoma assessment.
  • Virtual reality perimetry enhances accessibility, potentially broadening the integration of functional testing in glaucoma care.