Related Experiment Video
Updated: Jun 10, 2026
Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
Published on: May 25, 2020
Structure-Function Correlation of Virtual Reality and Standard Perimetry With Peripapillary RNFL OCT in Glaucoma
Maral Namdari1, Bryce Baugh1, Bangyan Zhang1
1John A. Moran Eye Center, University of Utah, Salt Lake City, UT, USA.
Purpose:
To compare the structure-function relationship of a virtual reality-based visual field test (Radius XR) with standard automated perimetry using either the SITA Fast or SITA Faster strategy, based on peripapillary retinal nerve fiber layer (pp-RNFL) thickness measured by spectral-domain optical coherence tomography (SD-OCT).
Methods:
This cross-sectional study included 116 eyes from 71 patients with glaucoma or suspected glaucoma. Participants underwent 24-2 visual field testing with Radius XR (RATA Fast) and a single standard automated perimetry strategy (either SITA Fast or SITA Faster). Peripapillary RNFL thickness was measured with SD-OCT within six months. Global and sectoral structure-function relationships were evaluated using linear mixed-effects models, with visual field locations mapped to corresponding peripapillary RNFL sectors based on the Garway-Heath map.
Results:
Structure-function associations between global pp-RNFL thickness and mean deviation were observed across testing modalities, with marginal R² values of 0.36 for Radius XR (RATA Fast), 0.43 for SITA Fast, and 0.29 for SITA Faster derived from linear mixed-effects models. Sectoral analyses demonstrated the strongest associations in the supratemporal and inferotemporal regions across all modalities.
Conclusions:
Radius XR achieved structure-function correlations comparable to standard automated perimetry, particularly in clinically relevant RNFL sectors, supporting its role in glaucoma assessment.
Translational Relevance:
Virtual reality-based perimetry provides structure-function relationships consistent with standard perimetry while improving accessibility, facilitating broader integration of functional testing into clinical and community-based glaucoma care.
