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Related Experiment Video

Updated: Jun 10, 2026

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
07:38

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection

Published on: May 10, 2024

Enhancing Preclinical Rigor: Evaluating Robustness and Numerical Stability in a Chronic Pancreatitis Mouse Model.

Annika Thämlitz1, Muhammad Imran Khan1, Benjamin Schulz1

  • 1Institute for Experimental Surgery, University Medical Centre Rostock, Rostock, Germany.

Annals of the New York Academy of Sciences
|June 9, 2026
PubMed
Summary
This summary is machine-generated.

This study validates a simplified chronic pancreatitis (CP) mouse model, demonstrating its reliability in replicating key disease hallmarks. The RORγt inhibitor GSK805 showed limited therapeutic effects in this robust CP model.

Keywords:
GSK805 therapycerulein‐induced chronic pancreatitisreliability of researchrobustness indexrobustness of conclusionunit fragility index

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Last Updated: Jun 10, 2026

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Area of Science:

  • Gastroenterology
  • Immunology
  • Toxicology

Background:

  • Chronic pancreatitis (CP) involves progressive fibrosis, inflammation, and pancreatic atrophy.
  • Developing reliable animal models is crucial for understanding CP pathogenesis and testing therapeutics.

Purpose of the Study:

  • To evaluate a simplified cerulein-induced chronic pancreatitis (CP) mouse model.
  • To assess the therapeutic potential of the RORγt inhibitor GSK805 in this CP model.
  • To validate the model's reliability using statistical metrics like robustness of conclusion (RC).

Main Methods:

  • Administration of 42 cerulein injections to male and female C57BL/6J (BL6) and BALB/c mice.
  • Evaluation of CP hallmarks: pancreas-to-body weight ratio, collagen I deposition, and tubular complex formation.
  • Assessment of inflammatory gene expression (Tnf, Ifng, Il10, Il23r, Il6, Il1b) and statistical robustness.

Main Results:

  • The CP model reliably reproduced key pathological features with 100% robustness of conclusion (RC).
  • Inflammatory gene induction varied by mouse strain and sex; Il23r and Il10 were induced in BL6 mice, while Il6 was induced in BALB/c mice.
  • GSK805 treatment significantly reduced Il23r expression in BL6 mice, but did not improve other CP characteristics.

Conclusions:

  • A simplified cerulein-induced CP model is robust and reliable for studying pancreatitis.
  • Inflammatory responses in CP models can be strain- and sex-specific.
  • The RORγt inhibitor GSK805 demonstrated limited efficacy in this CP model, highlighting the need for further therapeutic research.