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Related Experiment Video

Updated: Jun 10, 2026

Human Fetal Blood Flow Quantification with Magnetic Resonance Imaging and Motion Compensation
06:56

Human Fetal Blood Flow Quantification with Magnetic Resonance Imaging and Motion Compensation

Published on: January 7, 2021

Quantitative Cerebral Perfusion Monitoring Using Transit-Time Flow Measurement During Neonatal Aortic Arch Surgery: A

Valentina Orioli1, Lucio Careddu1, Marta Agulli2

  • 1From the Pediatric and Adult Congenital Heart Disease Cardiothoracic Surgery, Department of Cardio-Thoracic and Vascular Medicine, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS) AUC Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|June 9, 2026
PubMed
Summary
This summary is machine-generated.

Transit-time flow measurement (TTFM) offers real-time cerebral blood flow assessment during neonatal aortic arch surgery. This technique complements existing monitoring, enhancing the evaluation of brain perfusion in neonates undergoing complex cardiac repair.

Keywords:
cerebral perfusionneonatal surgeryneuromonitoringneuroprotection

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Last Updated: Jun 10, 2026

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Non-invasive Optical Measurement of Cerebral Metabolism and Hemodynamics in Infants

Published on: March 14, 2013

Area of Science:

  • Cardiovascular Surgery
  • Neonatal Intensive Care
  • Medical Device Technology

Background:

  • Neurological injury is a significant risk in neonatal aortic arch surgery.
  • Near-infrared spectroscopy (NIRS) monitors cerebral oxygenation but lacks direct cerebral blood flow data.
  • Accurate intraoperative monitoring of cerebral perfusion is crucial for neonates.

Purpose of the Study:

  • To evaluate the intraoperative utility of Transit-Time Flow Measurement (TTFM) for continuous cerebral inflow monitoring.
  • To assess TTFM's ability to provide quantitative cerebral blood flow data during neonatal aortic arch repair.
  • To determine if TTFM can complement conventional monitoring methods like NIRS.

Main Methods:

  • A perivascular flow probe was placed on the left common carotid artery for real-time flow measurement.
  • TTFM was used during cardiopulmonary bypass and selective cerebro-myocardial perfusion.
  • Carotid flow, waveform characteristics, and pulsatility index were analyzed throughout the procedure.

Main Results:

  • Baseline brachiocephalic trunk flow was ~87 ml/min; carotid flow stabilized at 45-50 ml/min during selective perfusion.
  • Aortic clamping altered the carotid waveform from pulsatile to continuous, reducing the pulsatility index from 1.5 to 0.6.
  • TTFM provided stable, quantitative cerebral inflow data consistent with arterial pressure and NIRS monitoring.

Conclusions:

  • Transit-Time Flow Measurement enables direct, real-time assessment of cerebral inflow during neonatal aortic arch repair.
  • TTFM provides quantitative data complementary to NIRS, enhancing cerebral perfusion monitoring.
  • This technique shows promise as a valuable adjunct for evaluating cerebral perfusion in complex neonatal cardiac surgery.