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Urine Aquaporin-5 a biomarker in diabetic nephropathy
Kamelia Ahmed Abdeen1, Radwa Mahmoud Elsharaby2, Ghada Mahmoud Alghazaly3
1Dr. Kamelia Ahmed Abdeen, Resident physician of Clinical Pathology, Tanta Fever Hospital kamilia%20138318@med.tanta.edu.eg , Kamelia.abdeen@gmail.com.
Aims:
The aim of this work was to investigate the value of urine aquaporin-5 (AQP-5) as a biomarker for diabetic nephropathy.
Methods:
an AQP5-specific enzyme-linked immunosorbent assay was used to measure urine AQP-5 in normal controls (n = 20), diabetic patients without nephropathy (n = 30) and diabetic nephropathy patients (n = 30). The data were analyzed by using SPSS 19.
Results:
urine AQP5/creatinine ratio was significantly higher in diabetic nephropathy patients than in other two groups. Urine AQP5/creatinine ratio in stage III& in stage V was significantly higher than that in stage II. Urine AQP5/creatinine ratio was significantly correlated with diabetes duration, HbA1C%, serum creatinine, blood urea nitrogen (BUN), albumin/creatinine ratio (ACR), urine AQP5, and estimated glomerular filtration rate (eGFR).
Conclusion:
This study suggests that urine AQP5/creatinine ratio may have diagnostic and prognostic values as a novel noninvasive biomarker of diabetic nephropathy.
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