Related Experiment Videos
Mycetoma caused by Streptomyces sudanensis
Maria Alessandra Mattioli1, Elisa Cinotti2, Pietro Rubegni2
1Department of Pathophysiology and Transplantation, Università degli Studi, IRCCS Foundation, Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Journal of Infection in Developing Countries
|June 9, 2026
Summary
This case study explores pulsed therapy for mycetoma, a deep skin infection. Pulsed gentamicin treatment may help prevent antibiotic resistance in Streptomyces sudanensis infections.
Area of Science:
- Dermatology
- Infectious Diseases
- Microbiology
Background:
- Mycetomas are deep, chronic skin infections.
- These infections can be caused by bacteria or fungi.
- Streptomyces species are a common bacterial cause of mycetoma.
Purpose of the Study:
- To report a case of mycetoma caused by Streptomyces sudanensis.
- To evaluate the efficacy of pulsed gentamicin therapy.
- To discuss strategies for preventing antibiotic resistance in mycetoma treatment.
Main Methods:
- A case of a foot mycetoma caused by Streptomyces sudanensis in an adult male.
- Treatment involved pulsed intramuscular gentamicin (80 mg/day) in six-week courses.
- Each course was followed by a three-week treatment interruption.
- The patient completed eight courses and continued the regimen.
Main Results:
- The patient is still undergoing pulsed gentamicin therapy.
- No specific outcomes regarding treatment success or failure are reported yet.
- The case highlights the administration of a prolonged, pulsed antibiotic regimen.
Conclusions:
- Pulsed therapy is a potential strategy for managing mycetoma.
- This approach may be beneficial in preventing the development of antibiotic resistance.
- Further research is needed to establish optimal pulsed therapy protocols for mycetoma.
Related Concept Videos
01:27Cryptococcal Meningitis
Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
01:29Fungal Group Zygomycota
Zygomycota, previously classified as a distinct fungal group, are primarily terrestrial, saprophytic molds that play a crucial role as decomposers. Recent phylogenetic studies have revealed that these fungi are now divided into two major clades — Mucoromycota, which includes many symbiotic species, and Zoopagomycota, which primarily consists of parasitic and pathogenic fungi. These groups exhibit distinct ecological roles and reproductive strategies while sharing key structural and...
01:23Skin Diseases and Disorders
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
01:26Rocky Mountain Spotted Fever
Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.
01:30Leishmaniasis
Leishmaniasis is a protozoal disease caused by species of the genus Leishmania and transmitted through the bite of infected female sandflies. The parasite exists in two principal morphological forms during its life cycle. A sandfly acquires intracellular amastigotes from an infected reservoir host, such as a dog. Within the sandfly, these forms differentiate into motile, flagellated promastigotes. During a subsequent blood meal, promastigotes are injected into the human host, where they...
01:28Fungal Phylum Microsporidia
Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...