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Related Concept Videos

Signal Transduction: Overview01:26

Signal Transduction: Overview

Cells respond to many types of information, often through receptor proteins positioned on the membrane. They respond to chemical signals, such as hormones, neurotransmitters, and other signaling molecules, initiating a series of molecular reactions to produce an appropriate response. This is called signal transduction. Cells also coordinate different responses elicited by the same signaling molecule via mediators, allowing molecular cross-talk.
Typically, signal transduction involves three...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:

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Related Experiment Video

Updated: Jun 11, 2026

The Establishment of a Lung Colonization Assay for Circulating Tumor Cell Visualization in Lung Tissues
07:39

The Establishment of a Lung Colonization Assay for Circulating Tumor Cell Visualization in Lung Tissues

Published on: June 16, 2018

Surfaceome Reprogramming of Stemsomes Promotes Lung Cancer Targeting via Potentiated Receptor-Ligand Interactions.

Geunhye Kim1, In Ah Kwon1,2, Bo Seop Jeong1

  • 1Department of Health Sciences and Technology, GAIHST, Gachon University, Incheon, South Korea.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|June 9, 2026
PubMed
Summary

Repurposing the anti-inflammatory drug dexamethasone enhances stem cell-derived nanovesicles (stemsomes) for non-small-cell lung cancer (NSCLC) therapy. This mutation-independent strategy improves tumor targeting by upregulating cell adhesion proteins, offering a universal treatment approach.

Keywords:
cell membrane‐derived vesicledexamethasoneliposomelung cancermesenchymal stem cell

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Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression
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Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression

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Last Updated: Jun 11, 2026

The Establishment of a Lung Colonization Assay for Circulating Tumor Cell Visualization in Lung Tissues
07:39

The Establishment of a Lung Colonization Assay for Circulating Tumor Cell Visualization in Lung Tissues

Published on: June 16, 2018

Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression
07:53

Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression

Published on: March 17, 2020

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Oncology

Background:

  • Non-small-cell lung cancer (NSCLC) poses a significant mortality challenge due to limited efficacy of mutation-specific therapies and acquired drug resistance.
  • Existing treatments often fail to address patients lacking identifiable oncogenic drivers, highlighting the need for universal therapeutic platforms.

Purpose of the Study:

  • To develop a novel, mutation-independent strategy for enhancing the tumor-targeting capabilities of mesenchymal stem cell-derived nanovesicles (stemsomes) for NSCLC treatment.
  • To investigate the repurposing of dexamethasone to improve stemsome efficacy in NSCLC therapy.

Main Methods:

  • Engineering nanoparticles by fusing dexamethasone-primed stemsomes with liposomes.
  • Utilizing transcriptomic and siRNA-mediated knockdown experiments to identify mechanisms of enhanced tumor targeting.
  • Conducting computational simulations to map potential adhesion interactions between engineered nanovesicles and NSCLC cells.

Main Results:

  • Dexamethasone priming significantly enhanced the tumor-targeting capabilities of stemsomes.
  • Enhanced targeting was attributed to dexamethasone-induced upregulation of cell adhesion proteins: ephrin type-A receptor 2 and neurogenic locus notch homolog protein 3.
  • A multivalent interaction network between dexamethasone-primed stemsomes and NSCLC cells was identified, suggesting improved therapeutic efficacy.

Conclusions:

  • Repurposing dexamethasone offers a novel strategy to enhance stemsome-based NSCLC therapy.
  • The developed nanoparticle system demonstrates a mutation-independent and highly translational approach for NSCLC treatment.
  • This research presents a promising new mechanism for engineering vesicle surfaces for effective NSCLC therapy.