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Published on: June 10, 2025

Association Between Hemoglobin-Creatinine Ratio and Six-Month All-Cause Readmission in Chinese Patients with Heart

Minghang Li1, Xuyang Li1, Zhang Ye2

  • 1The Second College of Clinical Medicine, Chongqing Medical University, Chongqing, China.

Archives of Medical Research
|June 9, 2026
PubMed

Insights

The hemoglobin-creatinine ratio (HBCR) can predict heart failure (HF) readmissions. Lower HBCR levels are linked to a higher risk of HF readmission within six months, suggesting its utility in patient risk stratification.

Area of Science:

  • Cardiology
  • Nephrology
  • Internal Medicine

Background:

  • Heart failure (HF) readmission is a significant global healthcare challenge.
  • Anemia (hemoglobin [Hb]) and renal dysfunction (creatinine [Cr]) are known HF risk factors.
  • The combined hemoglobin-creatinine ratio (HBCR) as a predictor for HF readmission needs further investigation.

Purpose of the Study:

  • To investigate the association between admission HBCR and six-month all-cause readmission in HF patients.
  • To determine if HBCR can identify high-risk HF patients for targeted interventions.

Main Methods:

  • Retrospective cohort study of 1,833 adult HF survivors.
  • HBCR calculated using admission Hb (g/L) and Cr (µmol/L).
  • Multivariable analysis adjusted for demographics, comorbidities, and laboratory values.

Main Results:

  • 37.6% of patients were readmitted within six months.
  • Lower admission HBCR correlated with increased readmission hazard.
  • Each SD increase in HBCR independently reduced readmission risk by 20% (aHR=0.80).
  • The highest HBCR tertile showed a 41% reduced readmission risk compared to the lowest (aHR=0.59).

Conclusions:

  • Admission HBCR is an independent predictor of six-month all-cause readmission in hospitalized HF patients.
  • HBCR may aid in identifying high-risk patients prior to discharge.
  • Further prospective studies are needed to confirm if HBCR-guided management impacts HF readmission rates.
Abstract

Keywords:
BiomarkersCreatinineHeart failureHemoglobinsPatient readmissionRetrospective studies

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