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Updated: Jun 11, 2026
07:29
Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
European consensus-based interdisciplinary guideline for invasive cutaneous squamous cell carcinoma: Part 2.
Alexander J Stratigos1, Clio Dessinioti1, Claus Garbe2
11st Department of Dermatology-Venereology, Andreas Sygros Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
European Journal of Cancer (Oxford, England : 1990)
|June 9, 2026
Summary
Updated guidelines recommend surgical excision for primary cutaneous squamous cell carcinoma (CSCC). For advanced CSCC, anti-PD-1 agents like cemiplimab are first-line, with multidisciplinary input crucial for complex cases.
Area of Science:
- Dermatology
- Oncology
- Medical Guidelines
Background:
- Invasive cutaneous squamous cell carcinoma (CSCC) requires updated treatment strategies.
- Immunocompetent and immunosuppressed patients present unique management challenges.
Purpose of the Study:
- To provide updated treatment recommendations for invasive CSCC.
- To incorporate current literature and expert consensus into clinical guidelines.
Main Methods:
- A multidisciplinary expert panel reviewed existing literature.
- Recommendations were developed based on evidence and consensus.
Main Results:
- First-line treatment for primary CSCC involves surgical excision with margin assessment.
- Anti-PD-1 agents (e.g., cemiplimab) are recommended for advanced CSCC.
- Multidisciplinary tumor board discussion is essential for complex cases, including metastatic or high-risk CSCC.
Conclusions:
- Updated guidelines emphasize surgical treatment for early-stage CSCC.
- Systemic therapy, particularly anti-PD-1 agents, plays a key role in advanced CSCC management.
- Shared decision-making and supportive care are vital for improving patient outcomes.
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