Osteoinductive self-assembling peptide hydrogel decorated with a biomimetic mineralization motif for bone repair

In view of the repair of bone defects in the field of oral cavity, traditional hydrogel materials face problems such as insufficient mechanical properties, limited biological activity, and mismatch between degradation rate and bone regeneration. To address this issue, we have embarked on the exploration and development of self-assembled peptide hydrogels as scaffold materials in the advanced field of bone tissue engineering, with the aim of overcoming the limitations of current treatment modalities. Currently, the design of intelligent self-assembled peptide hydrogels has become an innovative direction: the design is expected to break through the limitations of traditional hydrogels and promote the precise and personalized development of bone regeneration therapy through multi-dimensional biomimetics and intelligent control. By integrating loaded functional peptides and incorporating biomimetic modified materials, the synthesized self-assembled peptide hydrogel has been characterized to demonstrate its controllability and stability as a synthetic material. In vitro experiments have revealed its capacity to effectively guide the organized growth and proliferation of cells along its pore structure. Additionally, in vivo experiments have demonstrated its crucial role in the formation and maturation of new bone tissue. This can be attributed to their exceptional biocompatibility, distinctive degradability, minimal immunogenicity, and capacity to promote bone regeneration.