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Updated: Jun 11, 2026

Fabrication of polydimethylsiloxane (PDMS)-Based Flexible Surface-Enhanced Raman Scattering (SERS) Substrate for Ultrasensitive Detection

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Published on: November 17, 2023

A disposable paper-based sensor for phosphate detection using SERS technology.

Jie Chen¹, Wentao Zhou¹, Yijie Zeng¹

¹The School of Integrated Circuits, Southeast University, Nanjing, Jiangsu 210096, China.

Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy

|June 9, 2026

Summary

This summary is machine-generated.

A new paper-based sensor using surface-enhanced Raman spectroscopy (SERS) offers a simple, low-cost method for detecting phosphate in water. This rapid on-site monitoring tool helps assess water quality by quantifying phosphate levels effectively.

Keywords:

AKD AgNPs Paper-based sensor Phosphate detection R6G SERS

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Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor

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Published on: February 16, 2018

Area of Science:

Analytical Chemistry
Environmental Science
Materials Science

Background:

Elevated phosphate levels in aquatic systems drive eutrophication, degrading water quality.
There is a pressing need for accessible, on-site methods for phosphate monitoring.
Current methods are often complex, costly, or time-consuming for field applications.

Purpose of the Study:

To develop a disposable, paper-based sensor for sensitive and rapid detection of phosphate.
To utilize surface-enhanced Raman spectroscopy (SERS) for quantitative phosphate analysis.
To create a low-cost, user-friendly platform for on-site water quality assessment.

Main Methods:

Fabrication of a paper-based sensor using Whatman No. 1 filter paper with hydrophobic/hydrophilic zones created by Alkyl ketene dimer (AKD).
Development of a SERS sensing strategy based on an AgNPs-R6G system where phosphate presence suppresses the R6G signal.
Indirect quantitative detection of phosphate by measuring the decrease in SERS signal intensity.

Main Results:

The sensor demonstrated a linear response to phosphate concentrations ranging from 10^-7 M to 10^-2 M.
A low detection limit of 6.5 × 10^-8 M was achieved.
The assay requires minimal sample volume (50 μL) and a simple three-step procedure.

Conclusions:

The developed paper-based SERS sensor provides a sensitive, rapid, and cost-effective method for on-site phosphate detection.
The sensor's ease of fabrication and use makes it suitable for routine water quality monitoring.
This platform shows significant potential for improving environmental surveillance and preventing eutrophication.