Related Experiment Video
Updated: Jun 11, 2026
12:04
The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
Published on: November 1, 2015
Exhaustion in name only: CD8+ T cells drive lupus nephritis
Guillem Montamat-Garcia1, Claudia Mauri1
1Institute of Immunity and Transplantation, Division of Infection and Immunity, Royal Free Hospital, University College London, London NW3 2PP, UK.
Immunity
|June 9, 2026
Abstract:
Systemic lupus erythematosus is characterized by autoantibodies against nuclear antigens. In this issue of Immunity, Al Souz et al. report that kidney damage in lupus nephritis is sustained by stem-like CD8+ T cells that migrate from lymphoid tissues and then, driven by CD4+ T cells and IL-15 and IL-21, differentiate into cytotoxic effectors within tissue and retain pathogenic function despite exhaustion markers.
