Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
Long-term Depression01:05

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Long-term Depression01:03

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over time, all...
Depression: Overview01:18

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cognitive Flexibility and Bilingual Language Switching: An fMRI Meta-Analysis.

The European journal of neuroscience·2026
Same author

Safety and efficacy of decompressive craniectomy versus standard craniotomy for large acute epidural haematoma with tentorial herniation in China (PREDICT-AEDH): a nationwide, multicentre, open-label, parallel-group, randomised controlled trial.

The Lancet. Neurology·2026
Same author

Embodied language and early motor restriction: evidence from children with obstetric brachial plexus palsy and arthrogryposis.

Frontiers in psychology·2026
Same author

Recent advances in nanomaterial-based strategies for chronic pain alleviation.

Materials today. Bio·2026
Same author

Oral JAK inhibitors combined with 308-nm excimer laser in pediatric progressive vitiligo: Further considerations and future directions.

Journal of the American Academy of Dermatology·2026
Same author

Validation of novel naturalistic limb movement stimuli for studying biological motion perception in adults.

Frontiers in human neuroscience·2026

Related Experiment Video

Updated: Jun 11, 2026

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder
04:33

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

Published on: April 26, 2024

Integrative profiling of glymphatic dysfunction in adolescent subthreshold depression.

Qiwei Guo1, Ruisi Wang2, Zhongli Lan3

  • 1Faculty of Health Sciences, University of Macau, Taipa, Macau; Centre for Cognitive and Brain Sciences, University of Macau, Taipa, Macau.

Journal of Affective Disorders
|June 9, 2026
PubMed
Summary

Adolescents with subthreshold depression (StD) show altered brain glymphatic function, indicated by multimodal MRI changes. These findings suggest glymphatic MRI alterations may be a neurobiological feature of adolescent StD.

Keywords:
AdolescentBOLD-CSF couplingGlymphatic systemMahalanobis distanceMultimodal MRISubthreshold depression

Related Experiment Videos

Last Updated: Jun 11, 2026

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder
04:33

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

Published on: April 26, 2024

Area of Science:

  • Neuroimaging
  • Adolescent Psychiatry
  • Glymphatic System Biology

Background:

  • Subthreshold depression (StD) in adolescents is a significant clinical concern with unclear neurobiological underpinnings.
  • Glymphatic function, crucial for brain waste clearance, is increasingly implicated in neurological disorders.

Purpose of the Study:

  • To investigate multimodal magnetic resonance imaging (MRI) alterations related to glymphatic function in adolescents with StD.
  • To identify specific glymphatic biomarkers and their association with clinical symptoms in adolescent StD.

Main Methods:

  • Recruited 107 adolescents (71 StD, 36 healthy controls) for multimodal MRI.
  • Assessed six glymphatic biomarkers: choroid plexus volume, BOLD-CSF coupling, CSF Hurst exponent, ALPS index, perivascular space volume, and basal forebrain cholinergic nucleus volume.
  • Utilized ANCOVA for group comparisons and partial correlations for biomarker-clinical associations, with Mahalanobis distance quantifying multivariate glymphatic profile deviations.

Main Results:

  • Adolescents with StD exhibited reduced BOLD-CSF coupling and lower left ALPS index compared to controls.
  • Lower left ALPS was associated with increased insomnia severity and self-rated depressive symptoms.
  • Lower CSF Hurst exponent correlated with higher PHQ-9 scores; Mahalanobis distance was elevated in StD and strongly associated with PHQ-9 severity.

Conclusions:

  • Adolescents with StD display a distinct multivariate glymphatic-related MRI profile characterized by altered BOLD-CSF coupling and reduced ALPS.
  • These glymphatic-related MRI alterations may represent a neurobiological feature of adolescent StD.
  • Findings support integrating multimodal MRI data for a comprehensive understanding of adolescent StD, rather than relying on single indirect markers.