Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Heart Failure V: Medical Management01:30

Heart Failure V: Medical Management

Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
Heart Failure IV: Classification and Diagnostic Evaluation01:30

Heart Failure IV: Classification and Diagnostic Evaluation

Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
Heart Failure VII: Nursing Interventions01:30

Heart Failure VII: Nursing Interventions

The first step in nursing management of a patient with heart failure involves thoroughly assessing the patient's medical history.Subjective Data: Obtain the patient's medical history of coronary artery disease, hypertension, myocardial infarction, and symptoms like dyspnea, orthopnea, and paroxysmal nocturnal dyspnea.Objective Data: Conduct a physical examination to identify findings such as jugular vein distention, pulmonary crackles, tachycardia, murmurs, peripheral edema, and vital signs,...
Heart Failure Drugs: Diuretics01:22

Heart Failure Drugs: Diuretics

Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Delirium Among Adults Undergoing Transcatheter Structural Heart Intervention: Incidence, Risk, and Clinical Phenotypes.

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions·2026
Same author

Congenital Heart Disease in a Paralympic Athlete With Klinefelter Syndrome.

JACC. Case reports·2026
Same author

Filamin C Genetic Cardiomyopathy Presenting as Acute Myocardial Injury.

JACC. Case reports·2026
Same author

Managing Bleeding Risk in Older Adults: Antithrombotics and Anticoagulants.

Clinics in geriatric medicine·2026
Same author

Structural heart disease screening using artificial intelligence-enabled electrocardiogram and novice handheld cardiac ultrasound: a cost analysis.

European heart journal open·2026
Same author

Endovascular Repair of Type IA Endoleak With Zone 0 TBE and Carotid-Carotid-Subclavian Bypass.

JACC. Case reports·2026

Related Experiment Video

Updated: Jun 11, 2026

Clinical Application of Phase Angle and BIVA Z-Score Analyses in Patients Admitted to an Emergency Department with Acute Heart Failure
04:05

Clinical Application of Phase Angle and BIVA Z-Score Analyses in Patients Admitted to an Emergency Department with Acute Heart Failure

Published on: June 30, 2023

Clinical profiles to guide decongestion in acute heart failure.

Francisco B Alexandrino1, Sílvio Nunes Augusto2, Duarte Alexandrino3

  • 1Department of Internal Medicine, Primary Care Institute, Cleveland Clinic, Cleveland, OH.

American Heart Journal
|June 9, 2026
PubMed
Summary

Integrating diuretic resistance with residual congestion at 72 hours identified four acute heart failure profiles linked to 90-day risk. These profiles can help guide decongestion therapy and improve patient outcomes.

Related Experiment Videos

Last Updated: Jun 11, 2026

Clinical Application of Phase Angle and BIVA Z-Score Analyses in Patients Admitted to an Emergency Department with Acute Heart Failure
04:05

Clinical Application of Phase Angle and BIVA Z-Score Analyses in Patients Admitted to an Emergency Department with Acute Heart Failure

Published on: June 30, 2023

Area of Science:

  • Cardiology
  • Heart Failure Research
  • Clinical Trials

Background:

  • Residual congestion (RC) in acute heart failure (AHF) is associated with adverse outcomes.
  • Optimal decongestion targets beyond 48 hours in AHF are not well-defined.

Purpose of the Study:

  • To integrate diuretic resistance (DR) with RC at 72 hours post-treatment.
  • To develop actionable risk profiles for guiding decongestion in AHF patients.

Main Methods:

  • Post hoc pooled analysis of DOSE-AHF and ROSE-AHF trials (n=636).
  • Assessed 72-hour RC using clinical (Orthodema Score) and biomarker (NT-proBNP) criteria.
  • Defined diuretic resistance (DR) using BAN-ADHF scores.
  • Created four risk profiles: RC-/low DR, RC-/high DR, RC+/low DR, RC+/high DR.

Main Results:

  • 36% of patients experienced the primary outcome (90-day death, rehospitalization, or ED visit).
  • NT-proBNP-based RC definitions identified higher-risk patients (≤30% reduction: 1.7-fold higher risk).
  • Compared to RC-/low DR, risk increased stepwise: RC+/low DR (1.5-fold), RC-/high DR (1.8-fold), and RC+/high DR (1.9-fold).

Conclusions:

  • Integrating DR with 72-hour RC provides four actionable clinical profiles for risk stratification in AHF.
  • These profiles may help contextualize early treatment response and guide decongestion strategies.
  • Prospective validation is needed before clinical implementation of these findings.