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Related Experiment Video

Updated: Jun 11, 2026

Establishment and Characterization of Small Bowel Neuroendocrine Tumor Spheroids
09:43

Establishment and Characterization of Small Bowel Neuroendocrine Tumor Spheroids

Published on: October 14, 2019

Small Bowel Neuroendocrine Neoplasms.

Antonino Andrea Blandino1, Luigi Asmundo2, Elio Quiros3

  • 1Abdominal Radiology and Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Boston, MA; Section of Radiology - Department of Biomedicine, Neuroscience and Advanced Diagnostics (BiND), University Hospital "Paolo Giaccone", Palermo 90127, Italy.

Seminars in Ultrasound, CT, and MR
|June 9, 2026
PubMed
Summary

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Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the goblet,...

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Small bowel neuroendocrine neoplasms (SB-NENs) are heterogeneous tumors often diagnosed at advanced stages. This review highlights recent trends, classifications, and the crucial role of imaging in managing these challenging neuroendocrine tumors.

Area of Science:

  • Gastroenterology
  • Oncology
  • Radiology

Background:

  • Small bowel neuroendocrine neoplasms (SB-NENs) are a heterogeneous group of gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs).
  • These tumors frequently present with nonspecific symptoms and are often diagnosed at advanced metastatic stages, posing diagnostic and therapeutic challenges.
  • The biological heterogeneity and multifocal nature of SB-NENs complicate management.

Purpose of the Study:

  • To provide a comprehensive overview of SB-NENs.
  • To focus on recent epidemiological trends, updated classifications (2022 WHO, AJCC Staging System), and the role of imaging.
  • To emphasize the importance of imaging in diagnosis, staging, treatment planning, and response assessment.

Main Methods:

  • Review of recent epidemiological data.

Related Experiment Videos

Last Updated: Jun 11, 2026

Establishment and Characterization of Small Bowel Neuroendocrine Tumor Spheroids
09:43

Establishment and Characterization of Small Bowel Neuroendocrine Tumor Spheroids

Published on: October 14, 2019

  • Analysis of the 2022 World Health Organization (WHO) classification for GEP-NENs.
  • Evaluation of the American Joint Committee on Cancer (AJCC) Staging System.
  • Emphasis on the role of anatomical and molecular imaging modalities.
  • Discussion of the radiologist's contribution to surgical planning and follow-up strategies.

    • Main Results:

    • SB-NENs exhibit significant biological heterogeneity and a high rate of metastasis at diagnosis.
    • Nonspecific clinical presentation and small, multifocal lesions create diagnostic and therapeutic hurdles.
    • Imaging, encompassing both anatomical and molecular techniques, is central to SB-NEN management.
    • Radiology plays a key role in tumor detection, staging, surgical planning, and monitoring treatment response.

    Conclusions:

    • Accurate classification and staging are critical for managing SB-NENs.
    • Integrated imaging strategies are essential for comprehensive patient care.
    • Radiologists are integral to the multidisciplinary approach for optimizing outcomes in SB-NEN patients.