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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Radiation Therapy for Spinal Cord Tumors.

Aahan Arif¹, Thomas E Merchant¹

¹Department of Radiation Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

Neurosurgery Clinics of North America

|June 9, 2026

Summary

This review covers radiotherapy for pediatric and adult spinal cord tumors, like astrocytomas and ependymomas. It discusses treatment details, potential complications, and the benefits of proton therapy for children.

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Area of Science:

Radiation Oncology
Pediatric Oncology
Neurosurgery

Background:

Spinal cord tumors are rare but serious, requiring specialized management.
Radiotherapy is a key treatment modality for various spinal cord tumors.
Understanding optimal radiation techniques is crucial for both pediatric and adult patients.

Purpose of the Study:

To review the current radiotherapeutic management of pediatric and adult spinal cord tumors.
To highlight key considerations in radiotherapy planning and delivery.
To discuss the specific advantages of proton therapy in pediatric cases.

Main Methods:

Review of current literature on spinal cord tumor radiotherapy.
Analysis of indications, dose, and volume parameters for radiation.

Keywords:

Astrocytoma Complications Ependymoma Pediatric Proton therapy Radiotherapy Spinal cord tumor

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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

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Examination of potential complications and management strategies.

Inclusion of case examples illustrating individualized treatment approaches.

Main Results:

Radiotherapy indications vary based on tumor type (astrocytomas, ependymomas) and grade.
Careful dose and volume planning is essential to maximize efficacy and minimize toxicity.
Potential complications include bone weakening and spinal deformity, particularly in children.
Proton therapy offers potential advantages for pediatric patients due to precise dose delivery and reduced scatter.

Conclusions:

Individualized radiotherapy approaches are necessary, considering tumor characteristics and patient age.
Multidisciplinary care and long-term monitoring are vital for optimal outcomes.
Proton therapy represents a promising advancement for pediatric spinal cord tumor treatment.