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Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis
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Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis

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A new HANDling of progressive MS and progressive MS trials

Gavin Giovannoni1, Christopher H Hawkes1, Jeannette Lechner-Scott2

  • 1Blizard Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK.

Multiple Sclerosis and Related Disorders
|June 9, 2026
PubMed
Abstract

No abstract available in PubMed .

Keywords:
Length-dependent axonopathyMultiple sclerosisORATORIO-HANDProgressive multiple sclerosis

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Multiple Sclerosis l: Introduction01:19

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Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

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