Related Experiment Video
Updated: Jun 11, 2026
04:44
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Protocol for the INterstitial lung Disease EXacerbations (INDEX) Study: a retrospective multicentre cohort study
Amanda T Goodwin1,2,3, Giles Dixon4,5, Laura J White6,7
1NIHR Nottingham Respiratory Biomedical Research Centre, University of Nottingham, Nottingham, UK amanda.goodwin@nottingham.ac.uk.
BMJ Open Respiratory Research
|June 9, 2026
Summary
This study investigates respiratory hospitalizations in fibrotic interstitial lung disease (fILD), including acute exacerbations (AE-fILD). It aims to describe this patient population and identify factors influencing outcomes for better management strategies.
Area of Science:
- Pulmonology and Respiratory Medicine
- Clinical Research
- Epidemiology
Background:
- Hospitalizations for respiratory events significantly impact morbidity and mortality in fibrotic interstitial lung disease (fILD).
- Acute exacerbations (AE-fILD) are poorly understood, with limited management guidelines, especially for non-idiopathic pulmonary fibrosis (IPF) cases.
- Patients hospitalized for respiratory issues without meeting AE criteria represent an understudied group.
Purpose of the Study:
- To detail a large, real-world cohort of fILD patients hospitalized for respiratory events.
- To identify potential prognostic factors associated with these hospitalizations.
- To describe the characteristics and outcomes of patients with fILD experiencing respiratory-related hospital admissions.
Main Methods:
- A multicenter retrospective cohort study analyzing case notes from September 2022 to August 2023.
- Collection of demographic data, clinical features, investigation results, treatments, and mortality data.
- Primary outcome: 90-day transplant-free survival post-admission.
Main Results:
- Data collection and analysis are ongoing.
- The study will describe the characteristics of hospitalized fILD patients.
- Associations between patient factors, clinical presentation, treatment, and outcomes will be identified.
Conclusions:
- The study will improve understanding of respiratory hospital admissions in fILD, including AE-fILD.
- It will characterize a real-world fILD patient population and define current care standards.
- Findings may inform future clinical trials by identifying prognostic and treatment factors.
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