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Updated: Jun 11, 2026

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
07:55

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

Published on: April 11, 2018

Assessing and investigating children with suspected soft tissue sarcomas: an e-Delphi consensus process.

Lorna Ni Cheallaigh1, Timothy A Ritzmann2, Jo-Fen Liu3

  • 1UCL GOS Institute of Child Health, London, UK.

Archives of Disease in Childhood
|June 9, 2026
PubMed
Summary

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This summary is machine-generated.

Timely diagnosis of childhood soft tissue sarcoma (STS) is crucial for survival. This Delphi consensus developed clinical guidelines for healthcare professionals to improve early detection and management of pediatric STS.

Area of Science:

  • Pediatric Oncology
  • Clinical Guidelines
  • Diagnostic Challenges

Background:

  • Childhood soft tissue sarcoma (STS) presents diagnostic challenges, impacting patient survival.
  • Early diagnosis is critical for improving outcomes in pediatric STS.
  • This study aimed to develop clinical guidelines for healthcare professionals (HCPs) managing suspected pediatric STS.

Purpose of the Study:

  • To establish consensus among healthcare professionals on best practices for diagnosing and managing childhood soft tissue sarcoma (STS).
  • To inform the development of clinical guidelines for primary and secondary care settings.
  • To enhance early detection and referral pathways for pediatric STS.

Main Methods:

  • A Delphi consensus process involving healthcare professionals (HCPs).
Keywords:
Adolescent HealthChild HealthPaediatric Emergency MedicinePaediatrics

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Last Updated: Jun 11, 2026

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  • 48 statements derived from an evidence review were ranked using a 9-point Likert scale.
  • Multiple rounds of consensus building were conducted to refine statements.

    • Main Results:

    • High consensus (98%) was achieved on 47 out of 48 statements in the first round.
    • Strong agreement was reached on urgent referral, investigations, and secondary care consultation for suspected STS.
    • Barriers to timely diagnosis included logistical and systemic issues, necessitating increased HCP education and institutional support.

    Conclusions:

    • The consensus statements will form the basis of a clinical guideline for suspected STS in primary and secondary care.
    • The findings will be translated into public awareness tools for the Child Cancer Smart campaign.
    • Improved guidelines and awareness are expected to facilitate earlier diagnosis and better outcomes for children with STS.