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Related Experiment Video

Updated: Jun 11, 2026

Endoscopic Third Ventriculostomy and Pineal Biopsy from a Single Entry Point
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AOSNP-ADAPTR resource level-based recommendations on practical diagnostic strategies for ependymomas.

Laveniya Satgunaseelan1,2, Michael E Buckland1,2, Geeta Chacko3

  • 1Department of Neuropathology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.

Brain Pathology (Zurich, Switzerland)
|June 9, 2026
PubMed

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Interlaboratory performance testing on EPIC v2.0 CNS tumor profiling demonstrates high reproducibility of tumor classification but reveals the need for harmonized copy number variation reporting.

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Summary

This study offers practical guidelines for diagnosing ependymoma, a central nervous system (CNS) tumor, adapting advanced methods for resource-limited settings. The goal is to improve accessibility to accurate diagnosis and treatment for patients globally.

Area of Science:

  • Neuropathology
  • Oncology
  • Molecular Diagnostics

Background:

  • Ependymomas are rare central nervous system (CNS) tumors affecting both children and adults.
  • Molecular analyses have revealed diverse ependymal tumor subtypes, improving diagnostic precision and prognostication.
  • Current advanced diagnostic methods are often inaccessible in low- and lower-middle-income countries due to cost and technical barriers.

Purpose of the Study:

  • To propose practical, resource-level-adapted diagnostic guidelines for ependymoma.
  • To address the accessibility gap in CNS tumor diagnostics in resource-restrained regions.
  • To adapt World Health Organisation (WHO) Classification of Tumours of the Central Nervous System guidelines for routine use in diverse settings.

Main Methods:

  • Development of diagnostic approaches tailored to different levels of pathology resource availability.
Keywords:
AOSNP‐ADAPTRLMICsependymomasrecommendationsresource‐restrained regions

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  • Leveraging the ADAPTR group (Adapting Diagnostic Approaches for Practical Taxonomy in Resource-Restrained Regions) initiative.
  • Adaptation of established WHO CNS tumor classification guidelines.

    • Main Results:

    • A proposed practical approach for diagnosing ependymoma based on ADAPTR resource levels.
    • Guidelines designed for routine diagnostic application in resource-limited pathology laboratories.
    • Recommendations facilitate more accessible and precise ependymoma diagnosis globally.

    Conclusions:

    • The proposed ADAPTR guidelines offer a feasible pathway for diagnosing ependymomas in resource-restrained settings.
    • These adaptations aim to bridge the gap in diagnostic capabilities, improving patient outcomes.
    • The initiative supports equitable access to essential neuropathological diagnostics worldwide.