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Updated: Jun 11, 2026

Intestinal Epithelial Regeneration in Response to Ionizing Irradiation
Published on: July 27, 2022
Promoting intestinal regeneration without tumor risk in immune-mediated inflammatory diseases
Angélica Díaz-Basabe1, Ning He1, Eduardo J Villablanca2
1Division of Immunology and Respiratory Medicine, Department of Medicine Solna, Karolinska Institutet and University Hospital, Stockholm, Sweden; Center of Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
Abstract:
Immune-mediated inflammatory disorders, such as inflammatory bowel diseases, are characterized by chronic inflammation and damage to the intestinal barrier. Several of the current therapeutic strategies for inflammatory diseases attempt to decrease inflammation but cause side effects in a significant fraction of patients without promoting remission. Leveraging the power of intestinal regeneration for therapeutic purposes holds great promise, but it comes with the significant risk of promoting tumorigenesis, as most of the pathways that boost the regenerative program are also exploited by tumor cells for their growth and survival. In this article, we review the common mechanisms promoting intestinal regeneration and tumor development and discuss the latest studies identifying cellular and molecular pathways that promote regeneration but not tumorigenesis.
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