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Determination of the Photoisomerization Quantum Yield of a Hydrazone Photoswitch
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Published on: February 7, 2022

Highly sensitive X-ray responsive molecular switches.

Jiangang Li1, Kuanjian Wei1, Xiangmei Liu1

  • 1State Key Laboratory of Flexible Electronics (LoFE), Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, 9 Wenyuan Road, Nanjing, China.

Nature Communications
|June 9, 2026
PubMed
Summary
This summary is machine-generated.

This study introduces low-dose X-ray-triggered molecular switching using triplet excitons. This breakthrough enables remote control of molecular functions with unprecedented sensitivity and high-resolution imaging.

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Area of Science:

  • Materials Science
  • Chemistry
  • Physics

Background:

  • Existing X-ray-triggered molecular switches require high doses, limiting their practical application.
  • Remote control of molecular functions behind physical barriers remains a challenge.

Purpose of the Study:

  • To develop a low-dose X-ray-triggered molecular switching system.
  • To enable remote control of molecular functions in complex environments.
  • To achieve high-resolution X-ray imaging with molecular switches.

Main Methods:

  • Utilizing triplet-triplet energy transfer (TTET) from a scintillator to a photoswitch.
  • Designing flexible films with a Cu2I2(POP)2 scintillator and a hydrazone switch.
  • Employing HPLC, radical-scavenger tests, and time-resolved spectroscopy to elucidate the mechanism.

Main Results:

  • Achieved photoswitching at ~0.18 Gy, two orders of magnitude lower than previous systems.
  • Demonstrated a detection limit near 0.01 mGy.
  • Established a design rule for TTET based on triplet-level matching.
  • Enabled high-resolution radiography (3251 dpi) with long-term pattern retention (≥2 months).

Conclusions:

  • X-ray energy can be efficiently routed through triplet excitons for low-dose molecular switching.
  • This approach offers practical control of molecular functions in previously inaccessible environments.
  • The developed system provides a sensitive and high-resolution platform for X-ray imaging and molecular control.