Related Experiment Video
Updated: Jun 11, 2026

Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin
Published on: August 14, 2018
OrthoFinder: improved phylogenetic orthology inference with enhanced accuracy and scalability
David M Emms1, Yi Liu1, Laurence Belcher1
1Department of Biology, University of Oxford, Oxford, UK.
None:
Here we present a major advancement of the OrthoFinder method. This extends OrthoFinder's high-accuracy comparative genomic framework to provide substantially enhanced scalability and accuracy. Specifically, we show that enhanced phylogenetic delineation of orthogroups provides a 7% relative increase in orthogroup inference accuracy. We further demonstrate that a new gene assignment method substantially reduces overall runtime RAM usage without compromising accuracy. The latest version of OrthoFinder is available via GitHub at https://github.com/OrthoFinder/OrthoFinder .
Related Concept Videos
Phylogeny
Phylogenetic Trees
Phylogenetic Trees
Evolutionary Relationships through Genome Comparisons
Modern Molecular Taxonomy
Applications of Molecular Taxonomy

