Related Experiment Video
Updated: Jun 11, 2026

11:05
Behavioral Characterization of an Angelman Syndrome Mouse Model
Published on: October 20, 2023
Cannabidiol corrects sleep deficits and reduces spontaneous seizures in Angelman syndrome model mice
Tyler Shannon1, Mariam Najeeb1,2, Yoon-Jae Yi1
1Department of Neuroscience, The Ohio State University, Columbus, OH, USA.
Abstract:
The off-label use of cannabidiol (CBD) has outpaced investigation. We assessed the effects of CBD in Angelman syndrome model mice lacking the Ube3a gene and found that chronic injection of CBD increased rapid-eye movement sleep during the dark cycle, restored "Siesta", improved sleep homeostasis, and reduced spontaneous seizures following flurothyl kindling.

