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Soluble CD146 reflects altered endothelial and metabolic homeostasis in peripheral artery disease

Haizam Oubari1,2, Julien Labreuche3, Charlotte Reytier4

  • 1Center for Engineering in Medicine and Surgery, Department of Surgery, Harvard Medical School, Massachusetts General Hospital, États-Unis, Boston, MA, États-Unis d'Amérique.

Angiogenesis
|June 9, 2026
PubMed
Abstract

Insights

Lower levels of soluble CD146 (sCD146) are associated with Peripheral Arterial Disease (PAD). This finding suggests sCD146 may be a novel diagnostic biomarker for PAD, reflecting endothelial dysfunction.

Area of Science:

  • Cardiovascular Research
  • Biomarker Discovery
  • Endothelial Function

Background:

  • Peripheral Arterial Disease (PAD) is common and often underdiagnosed.
  • Soluble CD146 (sCD146) is linked to endothelial dysfunction and vascular congestion.

Purpose of the Study:

  • To investigate soluble CD146 (sCD146) as a potential novel biomarker for Peripheral Arterial Disease (PAD).
  • To assess the association between plasma sCD146 levels and PAD occurrence and severity.

Main Methods:

  • A case-control study compared 184 symptomatic PAD patients with 163 healthy controls.
  • PAD diagnosis was confirmed via ankle-brachial index (ABI) and imaging.
  • Plasma sCD146 levels were measured using ELISA, with associations analyzed via multivariable logistic regression.

Main Results:

  • sCD146 levels were significantly lower in PAD patients (288 ng/mL) compared to controls (480 ng/mL).
  • Each 10 ng/mL decrease in sCD146 increased PAD odds by 1.25 (OR, 95% CI 1.14-1.36).
  • sCD146 levels did not correlate with PAD severity but showed an inverse relationship with HDL-C in PAD patients.

Conclusions:

  • Lower plasma sCD146 concentration is independently associated with PAD.
  • The findings suggest sCD146 may indicate impaired endothelial homeostasis and metabolic issues in PAD.
  • sCD146 shows potential as a diagnostic biomarker for Peripheral Arterial Disease.
Keywords:
HDLPeripheral arterial diseaseSoluble CD146

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