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Assessing Mitochondrial Function in Sciatic Nerve by High-Resolution Respirometry
Published on: May 5, 2022
Mitochondrial Transfer from Glia to Neurons: A Novel Protective Mechanism Against Peripheral Neuropathy
Xiao-Wen Meng1,2, Yong-Jing Gao3
1Institute of Pain Medicine and Special Environmental Medicine, Nantong University, Nantong, 226019, China.
Neuroscience Bulletin
|June 9, 2026
Abstract
No abstract available in PubMed .
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DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...

