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Mitochondrial Transfer from Glia to Neurons: A Novel Protective Mechanism Against Peripheral Neuropathy

Xiao-Wen Meng1,2, Yong-Jing Gao3

  • 1Institute of Pain Medicine and Special Environmental Medicine, Nantong University, Nantong, 226019, China.

Neuroscience Bulletin
|June 9, 2026
PubMed
Abstract

No abstract available in PubMed .

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DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...

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