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Related Concept Videos

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
The Parathyroid Glands00:59

The Parathyroid Glands

The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by producing...

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Related Experiment Video

Updated: Jun 11, 2026

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
07:12

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging

Published on: August 17, 2022

Preoperative CALLY Index for Identifying Atypical Parathyroid Tumors.

Rıza Deryol1, Hilal Yıldırım Deryol2, Hakan Kırıt3

  • 1Department of Surgical Oncology, Istanbul Başakşehir Çam and Sakura City Hospital, Istanbul, Turkey.

Clinical Endocrinology
|June 9, 2026
PubMed
Summary

The C-reactive protein-albumin-lymphocyte (CALLY) index can help differentiate atypical parathyroid tumors from typical ones before surgery. A low CALLY index is a strong predictor of atypical parathyroid pathology.

Keywords:
CALLY indexatypical parathyroid tumorimmunonutritional biomarkersparathyroid adenomapreoperative risk stratificationprimary hyperparathyroidism

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Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
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Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

Related Experiment Videos

Last Updated: Jun 11, 2026

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
07:12

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging

Published on: August 17, 2022

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
03:57

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

Area of Science:

  • Endocrinology
  • Surgical Pathology
  • Oncology

Background:

  • Atypical parathyroid tumors (APTs) present diagnostic challenges due to worrisome features without meeting carcinoma criteria.
  • Current biochemical and imaging methods lack sufficient accuracy for reliable APT identification.
  • No validated preoperative biomarker exists to accurately distinguish APTs from benign adenomas.

Purpose of the Study:

  • To evaluate the C-reactive protein-albumin-lymphocyte (CALLY) index as a diagnostic marker for APTs.
  • To assess the CALLY index's performance in differentiating APTs from typical parathyroid adenomas (TPAs).

Main Methods:

  • Retrospective case-control study of 206 patients undergoing parathyroidectomy.
  • Included 50 histopathologically confirmed APT cases and 156 matched TPA controls.
  • Diagnostic accuracy assessed via ROC analysis; independent predictors identified using multivariable logistic regression.

Main Results:

  • The CALLY index was significantly lower in APTs (median 3.11) compared to TPAs (median 10.55).
  • ROC analysis showed excellent discrimination (AUC=0.941) with an optimal cutoff ≤ 5.73.
  • Low CALLY index was the strongest independent predictor of APT (OR: 37.29), outperforming other markers.

Conclusions:

  • The preoperative CALLY index shows potential as an accessible marker for identifying patients with increased likelihood of atypical parathyroid pathology.
  • The index is valuable for preoperative discrimination and risk stratification between APTs and TPAs.
  • Prospective multicenter validation is recommended prior to routine clinical use.