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Statistical optimization and characterization of diacerein-loaded Eudragit S-100 nanoparticles using a 32 factorial
Susanta Paul1, Dibya Sinha1, Ishita Sarkar1
1Department of Pharmaceutical Technology, NSHM Knowledge Campus, Kolkata - Group of Institutions, Kolkata, India.
Aims:
This study focused on developing an effective Rheumatoid Arthritis (RA) treatment by creating diacerein-loaded nanoparticles. The goal was to create a more efficient RA treatment with fewer side effects, something conventional treatments fail to achieve.
Materials And Methods:
Using the solvent evaporation technique, the researchers produced nanoparticles and formulated them, which they optimized using DOE (Design of Experiments). They also analyzed their nanoparticle formulations through three methods: particle size, entrapment efficiency, and in vitro drug release.
Results:
Their results indicate controlled drug release and desirable physical-chemical properties that should lead to greater bioavailability, which is a good thing because it leads to less waste. The in-vitro studies show that when using diacerein delivered through nanoparticles, there will be a greater anti-inflammatory response from chondrocytes than if diacerein were administered alone.
Conclusions:
Therefore, this study provides evidence that nanoparticles can be used to treat RA, improving drug effectiveness, decreasing systemic toxicity, and improving patient compliance.