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Published on: July 29, 2011
Ultrasonographic frequency of complex aortic plaques in patients with atrial fibrillation
Atilla Bulut1, Fadime Koca2, Yurdaer Donmez3
1Department of Cardiology, University of Health Sciences - Adana Health Practice and Research Center, Dr. Mithat Özsan Bulvarı Kışla Mah. 4522 Sok. No: 1 Yüreğir, Adana, Turkey. atilabulut@gmail.com.
Insights
Complex aortic plaque (CAP) affects 14.2% of atrial fibrillation (AF) patients, increasing stroke risk. Abdominal ultrasound can help stratify stroke risk in AF patients without known vascular disease.
Area of Science:
- Cardiology
- Vascular Medicine
- Medical Imaging
Background:
- Aortic plaque is a significant stroke risk factor in atrial fibrillation (AF) patients.
- Complex aortic plaque (CAP) presence is part of the CHA₂DS₂-VA score.
- Limited data exists on abdominal aortic plaque (AA-CAP) prevalence in AF patients.
Purpose of the Study:
- To determine the prevalence of AA-CAP in AF patients.
- To identify parameters associated with AA-CAP in this population.
Main Methods:
- 748 AF patients underwent abdominal ultrasonography (US) for AA-CAP assessment.
- Patients were evaluated clinically and via US.
- Population divided into AA-CAP positive and negative groups.
Main Results:
- AA-CAP detected in 14.2% of AF patients.
- AA-CAP patients were older, with higher CHA₂DS₂-VA scores and more cardiovascular risk factors.
- Independent predictors of AA-CAP included age, CHA₂DS₂-VA score, and hypertension.
Conclusions:
- AA-CAP is prevalent (14.2%) in AF patients.
- Abdominal US assessment of AA-CAP may aid stroke risk stratification in AF patients.
- AA-CAP evaluation can improve CHA₂DS₂-VA score accuracy for stroke risk assessment.
Background:
The presence of aortic plaque is an important risk factor for stroke in patients with atrial fibrillation (AF). A history of vascular disease, defined as the presence of complex aortic plaque (CAP), constitutes one of the components of the CHA₂DS₂-VA score. However, data regarding the frequency of abdominal aortic (AA) plaques in patients with AF are limited in the literature. Therefore, the present study aimed to investigate the prevalence of AA-CAP and its associated parameters in patients with AF.
Method:
A total of 748-patients with AF who underwent abdominal ultrasonography (US) for aortic plaque assessment were included in this study. In addition to routine clinical evaluations, all patients were assessed for the presence of AA-CAP using US. The study population was subsequently divided into two groups according to the presence or absence of AA-CAP.
Result:
AA-CAP was detected in 106 (14.2%) of the AF patients included in the study. Patients with AA-CAP were older and had higher CHA₂DS₂-VA scores and a greater burden of cardiovascular risk factors. In addition, blood pressure levels and glucose, urea, and creatinine values were higher, whereas hemoglobin levels were lower in patients with AA-CAP. In logistic regression analysis, age, CHA₂DS₂-VA score, and the presence of hypertension were found to be independently associated with AA-CAP (OR = 1.071,95%CI:1.031-1.111,p < 0.001;OR = 2.446,95%CI:1.900-3.149,p < 0.001;OR = 2.735,95%CI:1.441-5.190,p = 0.002). ROC curve analysis demonstrated that age and CHA₂DS₂-VA score, with cut-off values of 65 years and 3, respectively, identified the presence of AA-CAP with acceptable sensitivity and specificity.
Conclusion:
AA-CAP was observed at a considerable rate (14.2%) in patients with AF. Therefore, in AF patients without previously known coronary or peripheral arterial disease, assessment of AA-CAP using abdominal US may be useful for stroke risk stratification and for more accurate calculation of the CHA₂DS₂-VA score.
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