Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jun 11, 2026

Induction and Micro-CT Imaging of Cerebral Cavernous Malformations in Mouse Model

Induction and Micro-CT Imaging of Cerebral Cavernous Malformations in Mouse Model

Published on: September 4, 2017

Human stem cell models in cerebral cavernous malformations.

Qi Wang^1,2, Jiajun Sun^2,3, Xuesai Zhu²

¹Dalian Medical University, Dalian, China.

Stem Cell Research & Therapy

|June 10, 2026

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Bio-orthogonal Chemistry-Facilitated Zn-Mn Double-Layered Nanobombs Abrogate cGAS-STING Evasion of Tumor Cells.

Advanced healthcare materials·2026

Same author

Correction: Altered N170 and compensatory mechanisms in face processing in schizophrenia: an event-related potential study.

Frontiers in psychiatry·2026

Same author

Efficacy analysis of capsular tension ring ciliary sulcus suture fixation for lens subluxation.

BMC ophthalmology·2026

Same author

Strigolactones mediated regulation of leaf anatomy and divergent salt tolerance strategies in gramineous and leguminous forages.

Plant science : an international journal of experimental plant biology·2026

Same author

Optimal testing frequency for sexually transmitted infections among men who have sex with men and transgender women who use HIV pre-exposure prophylaxis in Australia, Brazil and Thailand: a cost-effectiveness analysis.

The Lancet regional health. Western Pacific·2026

Same author

A Clinical Study on the Improvement of Cognitive Function in Symptomatic Non-Acute Internal Carotid Artery Occlusion Patients with Hasan Type A and B.

Journal of visualized experiments : JoVE·2026

Human pluripotent stem cell models, particularly induced pluripotent stem cells (iPSCs), are revolutionizing cerebral cavernous malformation (CCM) research by enabling patient-specific disease modeling and drug screening.

Area of Science:

Neuroscience
Stem Cell Biology
Vascular Biology

Background:

Cerebral cavernous malformation (CCM) is a rare cerebrovascular disorder causing hemorrhage and neurological deficits.
Research is limited by animal models not fully recapitulating human neurovascular biology and restricted patient tissue access.
These limitations hinder mechanistic understanding and therapeutic development for CCM.

Purpose of the Study:

To review advances in CCM research utilizing human pluripotent stem cell (hPSC)-derived models.
To highlight how induced pluripotent stem cells (iPSCs) enable human-specific and patient-tailored CCM modeling.
To discuss the synergistic approach of stem cell models with traditional animal models.

Main Methods:

Utilizing induced pluripotent stem cells (iPSCs) to generate endothelial cells in 2D and 3D cultures.

Keywords:

CCM Disease modeling Stem cells Vascular malformation iPSCs

More Related Videos

Intrastriatal Injection of Autologous Blood or Clostridial Collagenase as Murine Models of Intracerebral Hemorrhage

Intrastriatal Injection of Autologous Blood or Clostridial Collagenase as Murine Models of Intracerebral Hemorrhage

Published on: July 3, 2014

Related Experiment Videos

Last Updated: Jun 11, 2026

Induction and Micro-CT Imaging of Cerebral Cavernous Malformations in Mouse Model

Induction and Micro-CT Imaging of Cerebral Cavernous Malformations in Mouse Model

Published on: September 4, 2017

Intrastriatal Injection of Autologous Blood or Clostridial Collagenase as Murine Models of Intracerebral Hemorrhage

Intrastriatal Injection of Autologous Blood or Clostridial Collagenase as Murine Models of Intracerebral Hemorrhage

Published on: July 3, 2014

Developing advanced platforms like vascular organoids and blood-brain barrier models.

Employing iPSC-based high-throughput drug screening for target validation and drug repurposing.

Main Results:

iPSC-derived endothelial cells provide mechanistic insights into CCM gene mutations (CCM1/2/3, PIK3CA) disrupting endothelial homeostasis.
Advanced models like vascular organoids better recapitulate the neurovascular microenvironment and cell interactions.
iPSC models facilitate drug screening, target validation, and personalized therapeutic strategy development.

Conclusions:

Stem cell-derived vascular models offer a robust framework for CCM research, overcoming limitations of previous models.
iPSC models are crucial for elucidating human-specific mechanisms and for drug discovery in CCM.
A hierarchical model selection strategy is proposed: iPSCs for mechanisms/drug screening, animal models for in vivo validation and disease progression.