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Published on: May 9, 2025

Danthron prevents pulmonary fibrosis through improving mitochondrial function by upregulating carboxylesterase 3

Boyu Li1, Rongman Xu1, Hongyan Zheng1

  • 1Department of Respiratory and Critical Care Medicine, National Clinical Research Center of Respiratory Disease, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Disease, Key Laboratory of Pulmonary Diseases of Health Ministry, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China.

Respiratory Research
|June 10, 2026
PubMed
Summary

Danthron, a natural compound, effectively treats pulmonary fibrosis (PF) by improving fibroblast function and enhancing mitochondrial health. This study highlights carboxylesterase 3 (CES3) as a key mediator and potential therapeutic target for PF.

Keywords:
CES3DanthronFibroblast activationMitochondriaPulmonary fibrosis

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