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Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Preventive Healthcare Services01:30

Preventive Healthcare Services

Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

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A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance
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A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

Published on: November 7, 2025

The 'Prostate Cancer Screening for People at Genetic Risk of Aggressive Disease' (PATROL) study.

Heather H Cheng1,2, Kara N Maxwell3, Keyan Salari4

  • 1Department of Medicine, University of Washington, Seattle, WA, USA.

BJU International
|June 10, 2026
PubMed
Summary

This study evaluates prostate cancer (PCa) screening in individuals with genetic risk variants (gPVs). It aims to refine early detection strategies using PSA levels and MRI for improved PCa diagnosis in high-risk men.

Keywords:
BRCA1/2early detectiongenetic riskprostate cancerprostate‐specific antigenriskscreening

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Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
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Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

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A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance
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A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

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Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
13:19

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

Area of Science:

  • Oncology
  • Genetics
  • Medical Imaging

Background:

  • Germline pathogenic variants (gPVs) in genes like BRCA2, ATM, and TP53 increase prostate cancer (PCa) risk.
  • National Comprehensive Cancer Network (NCCN) guidelines recommend enhanced PCa screening for gPV carriers.
  • Optimal early detection strategies, including PSA thresholds and imaging, require further refinement for gPV carriers.

Purpose of the Study:

  • To determine the positive predictive value of age-adjusted PSA levels and multiparametric MRI for detecting clinically significant PCa in individuals with gPVs.
  • To characterize clinicopathological features and patient-reported outcomes in this high-risk cohort.
  • To evaluate novel biomarkers using collected biospecimens.

Main Methods:

  • The 'Prostate Cancer Screening for People at Genetic Risk of Aggressive Disease' (PATROL) study is a prospective, multicentre trial.
  • Participants (≥40 years) with gPVs and no prior PCa diagnosis undergo annual PSA testing and optional MRI.
  • Prostate biopsy is recommended based on PSA levels and age-specific thresholds, with follow-up for up to 10 years.

Main Results:

  • This section is not applicable as the abstract does not contain results.
  • This section is not applicable as the abstract does not contain results.
  • This section is not applicable as the abstract does not contain results.

Conclusions:

  • This section is not applicable as the abstract does not contain conclusions.
  • This section is not applicable as the abstract does not contain conclusions.
  • This section is not applicable as the abstract does not contain conclusions.