Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of transcutaneous auricular vagus nerve stimulation combined with repetitive facilitative exercise on lower limb motor function in patients with intracerebral hemorrhage: A pilot randomized controlled trial.

PloS one·2026
Same author

ZER1 Restrains Pressure Overload-Induced Cardiac Remodeling by Targeting DVL2 for Gly/N-Degron-Dependent Degradation.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Meridian-sinew physical therapy modulates regional brain function and neurotransmitter spatial correlations in healthy volunteers: a neuroimaging study.

Frontiers in human neuroscience·2026
Same author

Effects of low-dose dietary antimicrobial peptide Scy-hepc on disease resistance in Larimichthys crocea under secondary infection.

BMC microbiology·2026
Same author

Curcumin attenuates hindlimb unloading-induced bone loss by suppressing NF-κB-mediated osteoclast activation.

Biochemical and biophysical research communications·2026
Same author

Alterations of White Matter Structural Brain Network in Children With Sensorineural Hearing Loss: A Graph Theory Analysis for Auditory Sensitivity Period.

Neural plasticity·2026

Related Experiment Video

Updated: Jun 11, 2026

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
14:27

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Published on: June 26, 2013

Network-Level Convergence of Adiposity-Related Gray Matter Alterations: A Coordinate-Based Connectome Mapping

Yingxian Li1, Mingnan Lin1, Gengbiao Zhang1

  • 1Department of Medical Imaging, The Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong Province, China.

Human Brain Mapping
|June 10, 2026
PubMed
Summary

Obesity is linked to brain gray matter reduction in specific networks. Weight loss increases gray matter in different brain systems, not a simple reversal, and involves molecular changes.

Keywords:
adipositygray matter volumeimaging transcriptomicsobesityvoxel‐based morphometry

More Related Videos

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
17:06

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
09:38

Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease

Published on: November 14, 2017

Related Experiment Videos

Last Updated: Jun 11, 2026

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
14:27

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Published on: June 26, 2013

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
17:06

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
09:38

Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease

Published on: November 14, 2017

Area of Science:

  • Neuroimaging
  • Systems Neuroscience
  • Obesity Research

Background:

  • Obesity is associated with gray matter changes, but affected brain regions vary across studies.
  • It's unclear if these changes form a consistent network or if weight loss impacts the same systems.

Purpose of the Study:

  • To identify brain networks associated with obesity-related gray matter reduction.
  • To determine if weight-loss-induced gray matter increases involve the same or different brain systems.
  • To explore molecular pathways linked to these structural changes.

Main Methods:

  • Meta-analysis of 38 voxel-based morphometry studies on obesity and weight loss.
  • Coordinate-based connectome mapping using resting-state functional connectivity.
  • Imaging transcriptomic and gene set enrichment analyses.

Main Results:

  • Adiposity-related gray matter reduction converged on frontoparietal control, cingulo-opercular, default mode, and Visual1 systems.
  • Weight-loss-related gray matter increases showed distinct patterns, primarily in cingulo-opercular, somatomotor, and dorsal attention systems.
  • Molecular analyses implicated mitochondrial energy metabolism, synaptic signaling, ion transport, and protein homeostasis.

Conclusions:

  • Adiposity-related gray matter alterations involve a reproducible network, but patterns differ between cross-sectional obesity and post-weight-loss changes.
  • Weight-loss effects on gray matter are not a direct reversal of obesity-related changes.
  • Coordinated molecular programs are associated with obesity-related structural brain alterations.