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Beyond Breathing: Lung as a Sensory Organ A Report from the NHLBI Workshop on Lung Sensing and its Implication in
Nicholas Jendzjowsky1, Christin S Kuo2, Leah R Reznikov3
1Division of Respiratory and Critical Care Medicine and Physiology, Department of Medicine, Harbor-UCLA Medical Center, The Lundquist Institute for Biomedical Innovation at Harbor-University of California, Los Angeles, Medical Center, Torrance, CA, 90502 USA.
Abstract:
The lung, one the largest branching organs in our body and vital for survival at first breath, is commonly known as the gas-exchange organ. Recent novel findings on lung sensing cells, molecules, and lung-brain crosstalk in the emerging discipline of interoception have highlighted the consideration of the lung as a sensory organ. Acknowledging the central importance of lung sensing to human health and disease, NHLBI convened a workshop to synthesize the past, current, and future of lung sensing research, with in-person presentations by ∼20 interdisciplinary experts and a large virtual audience. Here, we highlight the key topics discussed and summarize a blueprint for the future in this important field.
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