Efficacy and Safety of En-Bloc Laser Enucleation of the Prostate for Benign Prostatic Obstruction: An Evidence-Based Analysis of Clinical Studies
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Updated: Jun 11, 2026
Enucleation of the Prostate for the Treatment of Benign Prostatic Hyperplasia Using a 980 nm Diode Laser
Published on: May 5, 2020
Background And Objective:
This study compared the efficacy and safety of En-Bloc and standard techniques in laser enucleation, providing an evidence-based basis for surgical decision-making in the management of benign prostatic obstruction (BPO).
Methods:
Relevant studies were systematically identified through searches of PubMed, Embase, Web of Science, and Cochrane Library databases up to May 2025. Data analysis was performed using RevMan 5.4.
Results:
Data from 15 studies containing 9,397 participants were reviewed. The En-Bloc technique was associated with a reduction in enucleation time (mean difference [MD] - 8.43, 95% CI -13.0 to -3.91, p < 0.001), an increase in enucleation efficiency (MD 0.21, 95% CI 0.07 to 0.36, p = 0.004), a decrease in operative time (MD -4.70, 95% CI -8.81 to -0.60, p = 0.02), and a lower rate of major complications (odds ratio 0.62, 95% CI 0.42-0.90, p = 0.01) than the standard technique. No significant differences in postoperative short-term functional outcomes were found.
Conclusions:
The updated evidence suggests that the En-Bloc technique is associated with improved perioperative performance and a lower rate of major complications compared to the conventional approach, while preserving comparable functional outcomes. These findings suggest potential clinical benefits of En-Bloc enucleation in the surgical management of BPO.
