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Generation of Heterogeneous Drug Gradients Across Cancer Populations on a Microfluidic Evolution Accelerator for Real-Time Observation
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Published on: September 19, 2019

Dynamic precision oncology: from static mutation matching to adaptive tumor-host ecosystems

Takehiro Okabayashi1, Ryo Inada1, Motoyasu Tabuchi1

  • 1Department of Gastroenterological Surgery, Kochi Health Sciences Center, Kochi City, Kochi, Japan.

Expert Review of Anticancer Therapy
|June 10, 2026
PubMed
Summary

Precision oncology faces challenges beyond static genomic alterations, requiring dynamic integration of tumor evolution, host biology, and systemic factors for improved cancer care. Future strategies emphasize adaptive, longitudinal, and systems-based approaches for sustained patient benefit.

Keywords:
Precision oncologybiomarkersctDNAimplementation scienceresistancetumor evolution

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