Corrected Version: Protection of Mice from Controlled Cortical Impact Injury by Food Additive Glyceryl Tribenzoate

Area of Science:

• Neuroscience
• Pharmacology

Background:

• Traumatic brain injury (TBI) is a significant health issue with no effective treatments, often causing long-term disability.
• Current research seeks novel therapeutic strategies to mitigate TBI's damaging effects.

Purpose of the Study:

• To investigate the neuroprotective potential of glyceryl tribenzoate (GTB) in a mouse model of controlled cortical impact (CCI)-induced TBI.
• To evaluate GTB's effects on neuroinflammation, synaptic plasticity, and functional recovery after TBI.

Main Methods:

• Mice with CCI-induced TBI were orally administered GTB.
• Evaluated microglial and astrocyte activation, iNOS expression, synaptic markers (PSD-95, NR-2A, GluR1), lesion volume, and locomotor and spatial memory functions.

Main Results:

• GTB administration reduced microglial and astrocyte activation and iNOS expression in the hippocampus and cortex.
• GTB treatment preserved synaptic maturation markers and decreased lesion cavity size.
• Oral GTB improved locomotor activity and spatial learning and memory in TBI mice.

Conclusions:

• Glyceryl tribenzoate (GTB) exhibits significant neuroprotective effects against TBI in mice.
• GTB ameliorates TBI-induced neuroinflammation, synaptic damage, and functional deficits.
• GTB represents a potential therapeutic agent for managing traumatic brain injury.