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Grad-CAM based deep learning analytics for image-level colon disease classification based on graph neural networks
Chaohui Zhen1, Canhua Yao2, Song Li1
1Department of Gastrointestinal Surgery, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, Guangdong, China.
Frontiers in Physiology
|June 10, 2026
Summary
Vision Transformers (ViT) excel in colon disease classification, achieving 94.6% accuracy. Graph neural networks (GNNs) offer competitive performance, demonstrating deep learning
Area of Science:
- Medical Imaging
- Artificial Intelligence
- Computer Vision
Background:
- Accurate colonoscopic image classification is crucial for early colorectal disease detection.
- Deep learning models, including transformers and graph neural networks (GNNs), offer advanced methods for analyzing image data.
- These models can capture global context and relational structures vital for disease characterization.
Purpose of the Study:
- To evaluate transformer-based and graph-based deep learning frameworks for endoscopic colon disease classification.
- To compare the performance of Vision Transformers (ViT) against CNN-GNN pipelines.
- To assess the effectiveness of different graph construction strategies within GNNs.
Main Methods:
- Experiments utilized the Kvasir V2 dataset.
- A Vision Transformer (ViT) was selectively fine-tuned.
- A CNN-GNN pipeline integrated ViT embeddings with various graph construction methods (cosine similarity, k-NN, epsilon-radius) and GNN architectures.
- Performance metrics included accuracy, precision, recall, and macro-F1 score; Grad-CAM was used for interpretability.
Main Results:
- The fine-tuned Vision Transformer achieved 94.6% accuracy and a 0.94 macro-F1 score.
- The optimal graph-based approach, using ViT embeddings with an epsilon graph and GIN aggregation, reached 92% accuracy and a 0.92 macro-F1 score.
- Both transformer and graph-based methods demonstrated strong classification capabilities.
Conclusions:
- Transformer-based models show superior discriminative power for colon disease classification.
- Graph-based relational modeling provides competitive results when utilizing high-quality image embeddings.
- These findings highlight the potential of advanced deep learning techniques in improving endoscopic diagnostics.