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Related Experiment Video

Updated: Jun 11, 2026

A Method for Manipulating Blood Glucose and Measuring Resulting Changes in Cognitive Accessibility of Target Stimuli

A Method for Manipulating Blood Glucose and Measuring Resulting Changes in Cognitive Accessibility of Target Stimuli

Published on: August 12, 2016

Low- and no-calorie sweeteners and beverages and their associated health outcomes: an umbrella review of systematic

Jinyoung Jeong^1,2, Jaehyeong Cho^2,3, Yeona Jo^2,4

¹Department of Medicine, Kyung Hee University College of Medicine, Seoul 02447, Korea.

Nutrition Research and Practice

|June 10, 2026

Summary

This summary is machine-generated.

Long-term health effects of low- and no-calorie sweeteners (LNCSs) remain unclear. While observational studies link higher intake to risks like obesity and diabetes, randomized controlled trials show modest weight reduction in overweight individuals.

Keywords:

Beverages health sweetening agents systematic review

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Psychophysical Tracking Method to Measure Taste Preferences in Children and Adults

Psychophysical Tracking Method to Measure Taste Preferences in Children and Adults

Published on: July 16, 2016

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Last Updated: Jun 11, 2026

A Method for Manipulating Blood Glucose and Measuring Resulting Changes in Cognitive Accessibility of Target Stimuli

A Method for Manipulating Blood Glucose and Measuring Resulting Changes in Cognitive Accessibility of Target Stimuli

Published on: August 12, 2016

Psychophysical Tracking Method to Measure Taste Preferences in Children and Adults

Psychophysical Tracking Method to Measure Taste Preferences in Children and Adults

Published on: July 16, 2016

Area of Science:

Nutrition Science
Public Health
Metabolic Health

Background:

Long-term health effects of low- and no-calorie sweeteners (LNCSs) are not well-established.
Understanding these effects is crucial for public health guidance.

Purpose of the Study:

To systematically review associations between LNCSs and health outcomes.
To evaluate evidence from observational studies and randomized controlled trials (RCTs).

Main Methods:

Systematic search of multiple databases for meta-analyses up to December 2024.
Categorization of LNCSs and assessment of evidence quality using AMSTAR 2, credibility of evidence, and GRADE.
Reanalysis of eligible meta-analyses using random-effects models.

Main Results:

Included 29 meta-analyses covering over 50 million participants.
Observational studies linked higher non-sugar sweetener (NSS) intake to increased risks of overweight, metabolic syndrome, type 2 diabetes, and hypertension.
RCTs demonstrated that NSS consumption significantly decreased body weight in overweight/obese populations.

Conclusions:

LNCS use is associated with potential health risks, as indicated by observational data.
RCTs suggest modest weight reduction benefits in specific populations.
Further research is needed to clarify the long-term health impacts of LNCSs.